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Article

Proexosite-1-dependent recognition and activation of prothrombin by taipan venom.

The Journal of biological chemistry - 23 Apr 2004

Chen Lin, Rezaie Alireza R

Abstract excerpt

An activator complex from the venom of Oxyuranus scutellatus scutellatus (taipan venom) is known to rapidly activate prothrombin to thrombin. To determine whether, similar to prothrombinase, taipan venom utilizes proexosite-1 on prothrombin for a productive complex assembly, the activation of proexosite-1 mutants of prethrombin-1 by the partially purified venom was studied. It was discovered that basic residues...

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Identifiers

PMID: 14769787
DOI: 10.1074/jbc.M314285200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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