Article
Targeted mutation of the outer membrane protein P66 disrupts attachment of the Lyme disease agent, Borrelia burgdorferi, to integrin alphavbeta3.
Proceedings of the National Academy of Sciences of the United States of America - 10 Jun 2003
Coburn Jenifer, Cugini Carla
Abstract excerpt
Borrelia burgdorferi, the agent of Lyme disease, expresses several adhesion molecules that are probably required for initial establishment of infection in mammalian hosts, and for colonization of various tissues within the host. The B. burgdorferi outer membrane protein P66 was previously identified as a ligand for beta3-chain integrins by using a variety of biochemical approaches. Although the earlier data...
Topics
- Bacterial Adhesion
- Bacterial Proteins
- Binding Sites
- Borrelia burgdorferi
- Genes, Bacterial
- Humans
- In Vitro Techniques
- Integrin alphaVbeta3
- Lyme Disease
- Mutation
- Porins