Integrin binding by<scp><i>B</i></scp><i>orrelia burgdorferi</i> <scp>P</scp>66 facilitates dissemination but is not required for infectivity

Abstract excerpt

P66, a Borrelia burgdorferi surface protein with porin and integrin-binding activities, is essential for murine infection. The role of P66 integrin-binding activity in B. burgdorferi infection was investigated and found to affect transendothelial migration. The role of integrin binding, specifically, was tested by mutation of two amino acids (D205A,D207A) or deletion of seven amino acids (Del202-208). Neither...

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