Article
Elimination of channel-forming activity by insertional inactivation of the p66 gene in Borrelia burgdorferi.
FEMS microbiology letters - 1 Jan 2007
Pinne Marija, Thein Marcus, Denker Katrin, Benz Roland, Coburn Jenifer, Bergström Sven
Abstract excerpt
P66 is a chromosomally encoded 66-kDa integral outer membrane protein of the Lyme disease agent Borrelia burgdorferi exhibiting channel-forming activity. Herein, we inactivated and subsequently complemented the p66 gene in the B31-A (WT) strain. The P66 protein was also inactivated in two other channel-forming protein mutant strains, P13-18 (Deltap13) and Deltabba01, and then compared with the channel-forming...
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