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Article

Luteinizing hormone beta polymorphism and risk of familial and sporadic prostate cancer.

The Prostate - 15 Jun 2003

Elkins David A, Yokomizo Akira, Thibodeau Stephen N, J Schaid Daniel, Cunningham Julie M, Marks Angela, Christensen Eric, McDonnell Shannon K, Slager Susan, J Peterson Brett, J Jacobsen Steven, R Cerhan James, L Blute Michael, J Tindall Donald, Liu Wanguo

Abstract excerpt

BACKGROUND: Circulating testosterone plays an important role in maintenance and growth of prostate cells. Luteinizing hormone (LH), secreted from the anterior pituitary, signals testicular Leydig cells to secrete testosterone. A genetic variant of the LH-beta protein, LH-betaV, exists in up to 40% of Caucasians and is more bioactive than the wild-type protein. We hypothesized that genetically determined variation...

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Identifiers

PMID: 12746844
DOI: 10.1002/pros.10220

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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