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A Zinc Finger Protein, TbZC3H20, Stabilizes Two Developmentally Regulated mRNAs in Trypanosomes

6 Apr 2011

Abstract excerpt

CCCH zinc finger proteins (ZC3Hs) are a novel class of RNA-binding protein involved in post-transcriptional mechanisms controlling gene expression. We show TbZC3H20 from Trypanosoma brucei, the causative agent of sleeping sickness and other diseases, stabilizes two developmentally regulated transcripts encoding a mitochondrial carrier protein (MCP12) and trans-sialidase (TS-like E). TbZC3H20 is shown to be an...

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PMID: 21467035
DOI: 10.1074/jbc.m110.139261

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