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Article

Caudal dysgenesis in Islet-1 transgenic mice.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2003

Muller Yunhua Li, Yueh Yir Gloria, Yaworsky Paul J, Salbaum J Michael, Kappen Claudia

Abstract excerpt

Maternal diabetes during pregnancy is responsible for the occurrence of diabetic embryopathy, a spectrum of birth defects that includes heart abnormalities, neural tube defects, and caudal dysgenesis syndromes. Here, we report that mice transgenic for the homeodomain transcription factor Isl-1 develop profound caudal growth defects that resemble human sacral/caudal agenesis. Isl-1 is normally expressed in the...

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Identifiers

PMID: 12738808
DOI: 10.1096/fj.02-0856fje
PMCID: PMC3978111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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