Article
Minireview: transcriptional regulation in pancreatic development.
Endocrinology - 1 Mar 2005
Habener Joel F, Kemp Daniel M, Thomas Melissa K
Abstract excerpt
Considerable progress has been made in the understanding of the sequential activation of signal transduction pathways and the expression of transcription factors during pancreas development. Much of this understanding has been obtained by analyses of the phenotypes of mice in which the expression of key genes has been disrupted (knockout mice). Knockout of the genes for Pdx1, Hlxb9, Isl1, or Hex results in an...
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