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Article

Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 29 May 2007

Lin Lizhu, Cui Li, Zhou Wenlai, Dufort Daniel, Zhang Xiaoxue, Cai Chen-Leng, Bu Lei, Yang Lei, Martin Jody, Kemler Rolf, Rosenfeld Michael G, Chen Ju, Evans Sylvia M

Abstract excerpt

Recent studies have demonstrated that the LIM homeodomain transcription factor Islet1 (Isl1) marks pluripotent cardiovascular progenitor cells and is required for proliferation, survival, and migration of recently defined second heart field progenitors. Factors that are upstream of Isl1 in cardiovascular progenitors have not yet been defined. Here we demonstrate that beta-catenin is required for Isl1 expression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17519333
DOI: 10.1073/pnas.0700923104
PMCID: PMC1890491

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