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Article

p53-mediated apoptosis and genomic instability diseases.

Acta oncologica (Stockholm, Sweden) - 1 Jan 2001

Robles A I, Harris C C

Abstract excerpt

Mutations in several DExH-containing DNA helicases, including XPD, XPB, WRN, and BLM, are associated with rare familial cancer syndromes characterized by genomic instability and cancer susceptibility. Known cellular activities of these helicases include DNA replication, repair, recombination, and/or transcription. The p53 tumor suppressor is a regulator of cellular responses to stress, and is biochemically...

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Source

Identifiers

PMID: 11765063
DOI: 10.1080/02841860152619106

Genes

BLM
WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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