p53 and ageing: too much of a good thing?

Abstract excerpt

A recent report by Tyner et al.(1) suggests that p53 is bad for longevity. Heterozygotic mice carrying a p53 mutation that apparently enhances the stability of the wild-type protein showed shorter lifespans and faster ageing while also developing fewer tumours. This fits with the idea that cellular ageing is the price paid for better protection against unlimited proliferation of cancer cells. But other work shows...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Transformation, Neoplastic
• Share to DNA Damage
• Share to Mice