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Article

Alpha satellite DNA variant-specific oligoprobes differing by a single base can distinguish chromosome 15 homologs.

Genome research - 1 Sept 2000

O'Keefe C L, Matera A G

Abstract excerpt

The ability to distinguish homologous chromosomes is a powerful cytogenetic tool. However, traditional techniques can only distinguish extreme physical variants and are highly dependent on sample preparation. We have previously reported oligonucleotide probes, specific for human chromosome 17 alpha satellite DNA sequence variants, that distinguish cytogenetically normal homologous chromosomes by FISH. Here we...

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Share to Blotting, Southern
Share to Chromosomes, Human, Pair 15
Share to DNA, Satellite

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to In Situ Hybridization, Fluorescence

Share to Oligonucleotide Probes

Share to Pedigree

Share to Point Mutation

Share to Sequence Homology, Nucleic Acid

Source

Identifiers

PMID: 10984452
DOI: 10.1101/gr.10.9.1342

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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