Article
Genomic analysis of sequence variation in tandemly repeated DNA. Evidence for localized homogeneous sequence domains within arrays of alpha-satellite DNA.
Journal of molecular biology - 5 Nov 1990
Warburton P E, Willard H F
Abstract excerpt
As a model to examine the local distribution of sequence variation within large arrays of tandemly repeated DNA in complex genomes, the long-range organization of alpha-satellite DNA from human chromosome 17 was investigated. Three individual chromosomes, representing different alpha-satellite haplotypes, were segregated into mouse and human somatic cell hybrids and their arrays sized by pulse-field gel...
Topics
- Amino Acid Sequence
- Base Sequence
- Escherichia coli
- Genes, Bacterial
- Molecular Sequence Data
- Mutation
- Operon
- Plasmids
- Prephenate Dehydratase
- Protein Sorting Signals
- RNA, Transfer, Phe
