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Article

Genomic analysis of sequence variation in tandemly repeated DNA. Evidence for localized homogeneous sequence domains within arrays of alpha-satellite DNA.

Journal of molecular biology - 5 Nov 1990

Warburton P E, Willard H F

Abstract excerpt

As a model to examine the local distribution of sequence variation within large arrays of tandemly repeated DNA in complex genomes, the long-range organization of alpha-satellite DNA from human chromosome 17 was investigated. Three individual chromosomes, representing different alpha-satellite haplotypes, were segregated into mouse and human somatic cell hybrids and their arrays sized by pulse-field gel...

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PMID: 2122000
DOI: 10.1016/s0022-2836(05)80056-7

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