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Article

The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42.

Molecular and cellular neurosciences - 1 Dec 2002

Soltau Michaela, Richter Dietmar, Kreienkamp Hans-Jürgen

Abstract excerpt

The multidomain shank/ProSAP/SSTRIP proteins are major scaffold proteins in glutamatergic synapses in the mammalian brain; expression of shank1/SSTRIP in hippocampal neurons induces morphological changes in dendritic spines, suggesting that shank1 is involved in synapse formation and activity-dependent changes of synaptic structure. Using part of the proline-rich region of shank1 in a yeast two hybrid screen, we...

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Source

Identifiers

PMID: 12504591
DOI: 10.1006/mcne.2002.1201

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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