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Article

Characterisation of IRTKS, a novel IRSp53/MIM family actin regulator with distinct filament bundling properties.

Journal of cell science - 1 May 2007

Millard Thomas H, Dawson John, Machesky Laura M

Abstract excerpt

IRSp53 is a scaffold protein that contains an IRSp53/MIM homology domain (IMD) that bundles actin filaments and interacts with the small GTPase Rac. IRSp53 also binds to the small GTPase Cdc42 and to Scar/WAVE and Mena/VASP proteins to regulate the actin cytoskeleton. We have characterised a nove...

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Source

Identifiers

PMID: 17430976
DOI: 10.1242/jcs.001776

Genes

VASP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17430976-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Characterisation of IRTKS, a novel IRSp53/MIM family actin regulator with distinct filament bundling properties.PMID 17430976Read ↗

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