Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Involvement of syntaxin 7 in human gastric epithelial cell vacuolation induced by the Helicobacter pylori-produced cytotoxin VacA.

The Journal of biological chemistry - 11 Jul 2003

Suzuki Junko, Ohnishi Hirohide, Wada Akihiro, Hirayama Toshiya, Ohno Hideki, Ueda Namiki, Yasuda Hiroshi, Iiri Taroh, Wada Yoh, Futai Masamitsu, Mashima Hirosato

Abstract excerpt

The Helicobacter pylori-produced cytotoxin VacA induces intracellular vacuolation. The formed vacuole is assumed to be a hybrid of late endosome and lysosome. To elucidate the molecular mechanism of VacA-induced vacuolation, we examined the participation of syntaxin 7 in the human gastric epithel...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Northern
Share to Coloring Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Helicobacter pylori

Share to Luminescent Proteins

Share to Qa-SNARE Proteins

Share to Stomach

Share to Syntaxin 1

Share to Vacuoles

Source

Identifiers

PMID: 12730232
DOI: 10.1074/jbc.M212445200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12730232-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Involvement of syntaxin 7 in human gastric epithelial cell vacuolation induced by the Helicobacter pylori-produced cytotoxin VacA.PMID 12730232Read ↗

The small GTP binding protein rab7 is essential for cellular vacuolation induced by Helicobacter pylori cytotoxin.Semantic proximity Read ↗

Clustering and redistribution of late endocytic compartments in response to Helicobacter pylori vacuolating toxin.Semantic proximity Read ↗

There Are No Insurmountable Barriers: Passage of the Helicobacter pylori VacA Toxin from Bacterial Cytoplasm to Eukaryotic Cell OrganelleSemantic proximity Read ↗

Syntaxin 7 mediates endocytic trafficking to late endosomes.Semantic proximity Read ↗

Helicobacter pylori VacA toxin promotes bacterial intracellular survival in gastric epithelial cells.Semantic proximity Read ↗

Vacuolating cytotoxin A (VacA), a key toxin for Helicobacter pylori pathogenesisSemantic proximity Read ↗

Binding and internalization of the Helicobacter pylori vacuolating cytotoxin by epithelial cellsSemantic proximity Read ↗

A Helicobacter pylori vacuolating toxin mutant that fails to oligomerize has a dominant negative phenotype.Semantic proximity Read ↗

A dominant negative mutant of Helicobacter pylori vacuolating toxin (VacA) inhibits VacA-induced cell vacuolation.Semantic proximity Read ↗

Functional complementation reveals the importance of intermolecular monomer interactions for Helicobacter pylori VacA vacuolating activity.Semantic proximity Read ↗

Induction of gastric epithelial cell apoptosis by Helicobacter pylori vacuolating cytotoxin.Semantic proximity Read ↗

Role of Connexin 43 in Helicobacter pylori VacA-Induced Cell DeathSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.