Article
A Helicobacter pylori vacuolating toxin mutant that fails to oligomerize has a dominant negative phenotype.
Infection and immunity - 1 Mar 2006
Genisset Christophe, Galeotti Cesira L, Lupetti Pietro, Mercati David, Skibinski David A G, Barone Silvia, Battistutta Roberto, de Bernard Marina, Telford John L
Abstract excerpt
Most Helicobacter pylori strains secrete a toxin (VacA) that causes massive vacuolization of target cells and which is a major virulence factor of H. pylori. The VacA amino-terminal region is required for the induction of vacuolization. The aim of the present study was a deeper understanding of the critical role of the N-terminal regions that are protected from proteolysis when VacA interacts with artificial...
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