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Article

Clustering and redistribution of late endocytic compartments in response to Helicobacter pylori vacuolating toxin.

Molecular biology of the cell - 1 Apr 2004

Li Yi, Wandinger-Ness Angela, Goldenring James R, Cover Timothy L

Abstract excerpt

Helicobacter pylori VacA is a secreted protein toxin that may contribute to the pathogenesis of peptic ulcer disease and gastric adenocarcinoma. When added to cultured mammalian cells in the presence of weak bases (e.g., ammonium chloride), VacA induces the formation of large cytoplasmic vacuoles. Here, we report a previously unrecognized capacity of VacA to induce clustering and perinuclear redistribution of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 14742715
DOI: 10.1091/mbc.e03-08-0618
PMCID: PMC379289

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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