Article
The small GTP binding protein rab7 is essential for cellular vacuolation induced by Helicobacter pylori cytotoxin.
The EMBO journal - 2 Jan 1997
Papini E, Satin B, Bucci C, de Bernard M, Telford J L, Manetti R, Rappuoli R, Zerial M, Montecucco C
Abstract excerpt
The VacA cytotoxin, produced by toxigenic strains of Helicobacter pylori, induces the formation of large vacuoles highly enriched in the small GTPase rab7. To probe the role of rab7 in vacuolization, HeLa cells were transfected with a series of rab mutants and exposed to VacA. Dominant-negative m...
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