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Article

Separation of lipid transport functions by mutations in the extracellular domain of scavenger receptor class B, type I.

The Journal of biological chemistry - 11 Jul 2003

Connelly Margery A, De La Llera-Moya Margarita, Peng Yinan, Drazul-Schrader Denise, Rothblat George H, Williams David L

Abstract excerpt

Scavenger receptor class B, type I (SR-BI) shows a variety of effects on cellular cholesterol metabolism, including increased selective uptake of high density lipoprotein (HDL) cholesteryl ester, stimulation of free cholesterol (FC) efflux from cells to HDL and phospholipid vesicles, and changes in the distribution of plasma membrane FC as evidenced by increased susceptibility to exogenous cholesterol oxidase....

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Source

Identifiers

PMID: 12730208
DOI: 10.1074/jbc.M302820200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Separation of lipid transport functions by mutations in the extracellular domain of scavenger receptor class B, type I.PMID 12730208Read ↗

Scavenger receptor class B type I is a plasma membrane cholesterol sensor.Semantic proximity Read ↗

Tryptophan 415 Is Critical for the Cholesterol Transport Functions of Scavenger Receptor BI.Semantic proximity Read ↗

A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism.Semantic proximity Read ↗

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Functional characterization of newly-discovered mutations in human SR-BI.Semantic proximity Read ↗

Scavenger receptor class B, type I-mediated [3H]cholesterol efflux to high and low density lipoproteins is dependent on lipoprotein binding to the receptor.Semantic proximity Read ↗

Scavenger receptor class B type I-mediated cholesteryl ester-selective uptake and efflux of unesterified cholesterol. Influence of high density lipoprotein size and structure.Semantic proximity Read ↗

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Genetic studies in mice and humans reveal new physiological roles for the high-density lipoprotein receptor scavenger receptor class B type I.Semantic proximity Read ↗

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