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Article

Functional characterization of newly-discovered mutations in human SR-BI.

PloS one - 1 Jan 2012

Chadwick Alexandra C, Sahoo Daisy

Abstract excerpt

In rodents, SR-BI has been firmly established as a physiologically relevant HDL receptor that mediates removal of HDL-cholesteryl esters (CE). However, its role in human lipoprotein metabolism is less defined. Recently, two unique point mutations in human SR-BI - S112F or T175A - were identified in subjects with high HDL-cholesterol (HDL-C) levels. We hypothesized that mutation of these conserved residues would...

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Identifiers

PMID: 23029167
DOI: 10.1371/journal.pone.0045660
PMCID: PMC3448639

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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