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Article

Pharmacogenetics of ATP-binding cassette transporters in cancer and chemotherapy.

Molecular cancer therapeutics - 1 Jul 2003

Lockhart A Craig, Tirona Rommel G, Kim Richard B

Abstract excerpt

The ATP-binding cassette (ABC) transporters belong to the largest known transporter gene family and translocate a variety of substrates including chemotherapy agents. ABC multidrug transporter expression has been implicated in tumor cell resistance to anticancer therapy, altered disposition of chemotherapy drugs, and associated chemotherapy toxicity. More recently, genetic heterogeneity has been described in a...

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PMID: 12883042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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