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Article

POS5 gene of Saccharomyces cerevisiae encodes a mitochondrial NADH kinase required for stability of mitochondrial DNA.

Eukaryotic cell - 1 Aug 2003

Strand Micheline K, Stuart Gregory R, Longley Matthew J, Graziewicz Maria A, Dominick Olivia C, Copeland William C

Abstract excerpt

In a search for nuclear genes that affect mutagenesis of mitochondrial DNA in Saccharomyces cerevisiae, an ATP-NAD (NADH) kinase, encoded by POS5, that functions exclusively in mitochondria was identified. The POS5 gene product was overproduced in Escherichia coli and purified without a mitochondrial targeting sequence. A direct biochemical assay demonstrated that the POS5 gene product utilizes ATP to...

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Identifiers

PMID: 12912900
DOI: 10.1128/EC.2.4.809-820.2003
PMCID: PMC178377

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