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Article

SHH and FGF8 play distinct roles during development of noradrenergic neurons in the locus coeruleus of the zebrafish.

Molecular and cellular neurosciences - 1 Apr 2003

Lam Chen Sok, Sleptsova-Friedrich Inna, Munro Angus D, Korzh Vladimir

Abstract excerpt

Several signaling pathways have been implicated in the development of dopaminergic and serotonergic neurons. Here, we analyzed the formation of noradrenergic (NAergic) cells in the locus coeruleus (LC) of zebrafish. In the sonic hedgehog (shh) mutant, cells positive for tyrosine hydroxylase, a marker for putative NAergic cells in the LC were reduced. Similarly, the inhibition of translation of all hh genes and...

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Source

Identifiers

PMID: 12727446
DOI: 10.1016/s1044-7431(03)00031-9

Genes

FGF8
SHH
BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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