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Article

Lhx6 and Lhx8 coordinately induce neuronal expression of Shh that controls the generation of interneuron progenitors.

Neuron - 9 Jun 2011

Flandin Pierre, Zhao Yangu, Vogt Daniel, Jeong Juhee, Long Jason, Potter Gregory, Westphal Heiner, Rubenstein John L R

Abstract excerpt

Lhx6 and Lhx8 transcription factor coexpression in early-born MGE neurons is required to induce neuronal Shh expression. We provide evidence that these transcription factors regulate expression of a Shh enhancer in MGE neurons. Lhx6 and Lhx8 are also required to prevent Nkx2-1 expression in a sub...

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Identifiers

PMID: 21658586
DOI: 10.1016/j.neuron.2011.04.020
PMCID: PMC3153409

Genes

SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21658586-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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