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Article

Histone Acetylation and Gastrointestinal Carcinogenesis

1 Mar 2003

Abstract excerpt

The importance of altered histone acetylation in gastrointestinal carcinogenesis, especially in relation to invasion and metastasis, is described. Histone acetylation and chromatin remodeling linked with CpG island methylation play a major role in epigenetic regulation of gene expression. Acetylation of histones through an imbalance of histone acetyltransferases and deacetylases disrupts nucleosome structure,...

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PMID: 12724227
DOI: 10.1111/j.1749-6632.2003.tb05977.x

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