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Article

Transmission of ER stress response by ATF6 promotes endochondral bone growth

15 Sept 2015

Abstract excerpt

BACKGROUND: We reported earlier that X-box binding protein1 spliced (XBP1S), a key regulator of the unfolded protein response (UPR), as a bone morphogenetic protein 2 (BMP2)-inducible transcription factor, positively regulates endochondral bone formation by activating granulin-epithelin precursor (GEP) chondrogenic growth factor. Under the stress of misfolded or unfolded proteins in the endoplasmic reticulum...

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PMID: 26374329
DOI: 10.1186/s13018-015-0284-7

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