Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Definition of polymorphisms in the gene encoding the interleukin-12 receptor B1 subunit: testing linkage disequilibrium with Type I diabetes susceptibility.

Genes and immunity - 1 Apr 2003

Tabone T, Morahan G

Abstract excerpt

The cytokine interleukin (IL)-12 is bound by a heterodimeric receptor and mediates a range of immunological activities, in particular, favouring the development of uncommitted T cells to the Th1 phenotype. Genes encoding elements of the IL-12 pathway are therefore good candidates for mediating susceptibility or resistance to a range of immune disorders, including Type I diabetes. We made a systematic search for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Mellitus, Type 1
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Linkage Disequilibrium

Share to Polymorphism, Genetic

Share to Receptors, Interleukin

Share to Receptors, Interleukin-12

Source

Identifiers

PMID: 12700597
DOI: 10.1038/sj.gene.6363948

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Definition of polymorphisms in the gene encoding the interleukin-12 receptor B1 subunit: testing linkage disequilibrium with Type I diabetes susceptibility.PMID 12700597Read ↗

Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele.Semantic proximity Read ↗

Definition of polymorphisms and haplotypes in the interleukin-12B gene: association with IL-12 production but not with Crohn's disease.Semantic proximity Read ↗

IL-12Rβ1 deficiency: mutation update and description of the IL12RB1 variation database.Semantic proximity Read ↗

Evaluation of IL12B as a candidate type I diabetes susceptibility gene using data from the Type I Diabetes Genetics Consortium.Semantic proximity Read ↗

Genetic variations in the interleukin-12/interleukin-23 receptor (beta1) chain, and implications for IL-12 and IL-23 receptor structure and function.Semantic proximity Read ↗

Association study between interleukin-12 receptor beta1/beta2 genes and type 1 diabetes or asthma in the Japanese population.Semantic proximity Read ↗

Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1.Semantic proximity Read ↗

Differential expression and function of human IL-12Rβ2 polymorphic variants.Semantic proximity Read ↗

Genetic variations in interleukin-12 related genes in immune-mediated diseases.Semantic proximity Read ↗

Identification of IL12RB1 as a novel systemic sclerosis susceptibility locus.Semantic proximity Read ↗

Interleukin 12 and autoimmune diabetes.Semantic proximity Read ↗

Analysis of IL12B gene variants in inflammatory bowel disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.