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Article

Protection from endogenous perforin: glycans and the C terminus regulate exocytic trafficking in cytotoxic lymphocytes.

Immunity - 24 Jun 2011

Brennan Amelia J, Chia Jenny, Browne Kylie A, Ciccone Annette, Ellis Sarah, Lopez Jamie A, Susanto Olivia, Verschoor Sandra, Yagita Hideo, Whisstock James C, Trapani Joseph A, Voskoboinik Ilia

Abstract excerpt

Cytotoxic lymphocyte-mediated apoptosis is dependent on the delivery of perforin to secretory granules and its ability to form calcium-dependent pores in the target cell after granule exocytosis. It is unclear how cytotoxic lymphocytes synthesize and store perforin without incurring damage or dea...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21658975
DOI: 10.1016/j.immuni.2011.04.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21658975-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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