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EBNA2 and Activated Notch Induce Expression of BATF

28 Apr 2003

Abstract excerpt

The immortalization of human B lymphocytes by Epstein-Barr virus (EBV) requires the virus-encoded transactivator EBNA2 and the products of both viral and cellular genes which serve as EBNA2 targets. In this study, we identified BATF as a cellular gene that is up-regulated dramatically within 24 h following the infection of established and primary human B cells with EBV. The transactivation of BATF is mediated by...

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PMID: 12719594
DOI: 10.1128/jvi.77.10.6029-6040.2003

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