Article
Reduced IRF4 expression promotes lytic phenotype in Type 2 EBV-infected B cells.
PLoS pathogens - 1 Apr 2022
Bristol Jillian A, Brand Joshua, Ohashi Makoto, Eichelberg Mark R, Casco Alejandro, Nelson Scott E, Hayes Mitchell, Romero-Masters James C, Baiu Dana C, Gumperz Jenny E, Johannsen Eric C, Dinh Huy Q, Kenney Shannon C
Abstract excerpt
Humans are infected with two types of EBV (Type 1 (T1) and Type 2 (T2)) that differ substantially in their EBNA2 and EBNA 3A/B/C latency proteins and have different phenotypes in B cells. T1 EBV transforms B cells more efficiently than T2 EBV in vitro, and T2 EBV-infected B cells are more lytic. We previously showed that both increased NFATc1/c2 activity, and an NFAT-binding motif within the BZLF1 immediate-early...
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