Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interrogation of a lacrimo-auriculo-dento-digital syndrome protein reveals novel modes of fibroblast growth factor 10 (FGF10) function.

The Biochemical journal - 15 Dec 2016

Mikolajczak Marta, Goodman Timothy, Hajihosseini Mohammad K

Abstract excerpt

Heterozygous mutations in the gene encoding fibroblast growth factor 10 (FGF10) or its cognate receptor, FGF-receptor 2 IIIb result in two human syndromes - LADD (lacrimo-auriculo-dento-digital) and ALSG (aplasia of lacrimal and salivary glands). To date, the partial loss-of-FGF10 function in these patients has been attributed solely to perturbed paracrine signalling functions between FGF10-producing mesenchymal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Abnormalities, Multiple
Share to Active Transport, Cell Nucleus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblast Growth Factor 10

Share to Hearing Loss

Share to HEK293 Cells

Share to Protein Transport

Share to Syndactyly

Share to Tooth Abnormalities

Source

Identifiers

PMID: 27742760
DOI: 10.1042/BCJ20160441

Genes

FGF10

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interrogation of a lacrimo-auriculo-dento-digital syndrome protein reveals novel modes of fibroblast growth factor 10 (FGF10) function.PMID 27742760Read ↗

LADD syndrome is caused by FGF10 mutations.Semantic proximity Read ↗

High molecular weight FGF2: the biology of a nuclear growth factor.Semantic proximity Read ↗

Nucleolar localization of parafibromin is mediated by three nucleolar localization signals.Semantic proximity Read ↗

Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands.Semantic proximity Read ↗

Mutations in different components of FGF signaling in LADD syndrome.Semantic proximity Read ↗

Plakophilins 1a and 1b: widespread nuclear proteins recruited in specific epithelial cells as desmosomal plaque componentsSemantic proximity Read ↗

Structural basis for reduced FGFR2 activity in LADD syndrome: Implications for FGFR autoinhibition and activation.Semantic proximity Read ↗

Translokin is an intracellular mediator of FGF-2 trafficking.Semantic proximity Read ↗

Parafibromin is a nuclear protein with a functional monopartite nuclear localization signal.Semantic proximity Read ↗

Fgf10 Gene Dosage from a Single Allele Is Insufficient for Forming Multilayered Epithelial Cells in the Murine Lacrimal Gland.Semantic proximity Read ↗

Different abilities of the four FGFRs to mediate FGF-1 translocation are linked to differences in the receptor C-terminal tail.Semantic proximity Read ↗

Biochemical analyses of the AF10 protein: the extended LAP/PHD-finger mediates oligomerisation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.