Article
Fibroblast growth factor 2 (FGF-2) is a novel substrate for arginine methylation by PRMT5.
Biological chemistry - 1 Jan 2009
Bruns Alexander-Francisco, Grothe Claudia, Claus Peter
Abstract excerpt
Fibroblast growth factor 2 (FGF-2) is expressed in isoforms of different molecular masses from one mRNA species by alternative start of translation. The higher molecular mass isoforms (FGF-2(21) and (23)) contain an arginine-rich N-terminus organized in RG-motifs followed by the 18 kDa FGF-2 (FGF-2(18)) core which is common to all isoforms. Both isoforms localize differentially to the nucleus. Here, we analyzed...
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