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Article

Specific compositions of amyloid-beta peptides as the determinant of toxic beta-aggregation.

The Journal of biological chemistry - 27 Jun 2003

Yoshiike Yuji, Chui De-Hua, Akagi Takumi, Tanaka Nobuo, Takashima Akihiko

Abstract excerpt

Alzheimer's disease (AD) may be caused by toxic aggregates formed from amyloid-beta (Abeta) peptides. By using Thioflavin T, a dye that specifically binds to beta-sheet structures, we found that highly toxic forms of Abeta-aggregates were formed at the initial stage of fibrillogenesis, which is consistent with recent reports on Abeta oligomers. Formation of such aggregates depends on factors that affect both...

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PMID: 12716908
DOI: 10.1074/jbc.M212785200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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