Article
Two distinct β-sheet structures in Italian-mutant amyloid-beta fibrils: a potential link to different clinical phenotypes.
Cellular and molecular life sciences : CMLS - 1 Dec 2015
Hubin Ellen, Deroo Stéphanie, Schierle Gabriele Kaminksi, Kaminski Clemens, Serpell Louise, Subramaniam Vinod, van Nuland Nico, Broersen Kerensa, Raussens Vincent, Sarroukh Rabia
Abstract excerpt
Most Alzheimer's disease (AD) cases are late-onset and characterized by the aggregation and deposition of the amyloid-beta (Aβ) peptide in extracellular plaques in the brain. However, a few rare and hereditary Aβ mutations, such as the Italian Glu22-to-Lys (E22K) mutation, guarantee the development of early-onset familial AD. This type of AD is associated with a younger age at disease onset, increased β-amyloid...
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