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Article

The Alzheimer disease protective mutation A2T modulates kinetic and thermodynamic properties of amyloid-β (Aβ) aggregation.

The Journal of biological chemistry - 7 Nov 2014

Benilova Iryna, Gallardo Rodrigo, Ungureanu Andreea-Alexandra, Castillo Cano Virginia, Snellinx An, Ramakers Meine, Bartic Carmen, Rousseau Frederic, Schymkowitz Joost, De Strooper Bart

Abstract excerpt

Missense mutations in alanine 673 of the amyloid precursor protein (APP), which corresponds to the second alanine of the amyloid β (Aβ) sequence, have dramatic impact on the risk for Alzheimer disease; A2V is causative, and A2T is protective. Assuming a crucial role of amyloid-Aβ in neurodegeneration, we hypothesized that both A2V and A2T mutations cause distinct changes in Aβ properties that may at least...

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Identifiers

PMID: 25253695
DOI: 10.1074/jbc.M114.599027
PMCID: PMC4223304

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APP

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