Generic hydrophobic residues are sufficient to promote aggregation of the Alzheimer's Abeta42 peptide.

Abstract excerpt

One hundred years ago, Alois Alzheimer observed a relationship between cognitive impairment and the presence of plaque in the brains of patients suffering from the disease that bears his name. The plaque was subsequently shown to be composed primarily of a 42-residue peptide called amyloid beta (Abeta) 42. Despite the importance of Abeta42 aggregation in the molecular etiology of Alzheimer's disease, the amino...

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