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Article

A ganglioside-induced toxic soluble Abeta assembly. Its enhanced formation from Abeta bearing the Arctic mutation.

The Journal of biological chemistry - 26 Jan 2007

Yamamoto Naoki, Matsubara Etsuro, Maeda Sumihiro, Minagawa Hirohisa, Takashima Akihiko, Maruyama Wakako, Michikawa Makoto, Yanagisawa Katsuhiko

Abstract excerpt

The mechanism underlying plaque-independent neuronal death in Alzheimer disease (AD), which is probably responsible for early cognitive decline in AD patients, remains unclarified. Here, we show that a toxic soluble Abeta assembly (TAbeta) is formed in the presence of liposomes containing GM1 ganglioside more rapidly and to a greater extent from a hereditary variant-type ("Arctic") Abeta than from wild-type...

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Identifiers

PMID: 17135262
DOI: 10.1074/jbc.M606202200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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