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Article

The structure of serine hydroxymethyltransferase as modeled by homology and validated by site-directed mutagenesis.

Protein science : a publication of the Protein Society - 1 Sept 1998

Pascarella S, Angelaccio S, Contestabile R, Delle Fratte S, Di Salvo M, Bossa F

Abstract excerpt

We describe a model for the three-dimensional structure of E. coli serine hydroxymethyltransferase based on its sequence homology with other PLP enzymes of the alpha-family and whose tertiary structures are known. The model suggests that certain amino acid residues at the putative active site of the enzyme can adopt specific roles in the catalytic mechanism. These proposals were supported by analysis of the...

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Identifiers

PMID: 9761478
DOI: 10.1002/pro.5560070913
PMCID: PMC2144154

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