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Article

Reflections on the catalytic power of a TIM-barrel.

Bioorganic chemistry - 1 Dec 2014

Richard John P, Zhai Xiang, Malabanan M Merced

Abstract excerpt

The TIM-barrel fold is described and its propagation throughout the enzyme universe noted. The functions of the individual front loops of the eponymous TIM-barrel of triosephosphate isomerase are presented in a discussion of: (a) electrophilic catalysis, by amino acid side chains from loops 1 and 4, of abstraction of an α-carbonyl hydrogen from substrate dihydroxyacetone phosphate (DHAP) or d-glyceraldehyde...

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Source

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Identifiers

PMID: 25092608
DOI: 10.1016/j.bioorg.2014.07.001
PMCID: PMC4256097

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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