Article
What is, mutatis mutandis, the sequence of plasmid DNAs used in gene therapy?
Medical hypotheses - 1 May 2003
Ratel David, Wion Didier
Abstract excerpt
Mutation is a fundamental biological process occurring in each living organism. Plasmid DNA which is used in gene therapy protocols or DNA vaccination passes through two different living cells which are, respectively, the producing cell (bacterial) and the target cell (eukaryotic). Hence, modifications in the nucleotide sequence of plasmids are likely to occur both in bacteria during the amplification step of...
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