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Plasmid DNA Manufacturing for Indirect and Direct Clinical Applications

22 Aug 2017

Abstract excerpt

Plasmid DNA is currently gaining increasing importance for clinical research applications in gene therapy and genetic vaccination. For direct gene transfer into humans, good manufacturing practice (GMP)-grade plasmid DNA is mandatory. The same holds true if the drug substance contains a genetically modified cell, for example chimeric antigen receptor (CAR) T cells, where these cells as well as the contained...

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PMID: 28826233
DOI: 10.1089/hum.2017.159

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