Article
Mutation detection in plasmid-based biopharmaceuticals.
Biotechnology journal - 1 Apr 2011
Oliveira Pedro H, Prather Kristala L J, Prazeres Duarte M F, Monteiro Gabriel A
Abstract excerpt
As the number of applications involving therapeutic plasmid DNA (pDNA) increases worldwide, there is a growing concern over maintaining rigorous quality control through a panel of high-quality assays. For this reason, efficient, cost-effective and sensitive technologies enabling the identification of genetic variants and unwanted side products are needed to successfully establish the identity and stability of a...
Topics
- DNA
- Genomic Instability
- Humans
- Mutation
- Plasmids
- Vaccines, DNA