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Article

Modulation of Rho GTPase signaling regulates a switch between adipogenesis and myogenesis.

Cell - 18 Apr 2003

Sordella Raffaella, Jiang Wei, Chen Guang-Chao, Curto Marcello, Settleman Jeffrey

Abstract excerpt

Mature adipocytes and myocytes are derived from a common mesenchymal precursor. While IGF-1 promotes the differentiation of both cell types, the signaling pathways that specify the distinct cell fates are largely unknown. Here, we show that the Rho GTPase and its regulator, p190-B RhoGAP, are components of a critical switch in the adipogenesis-myogenesis "decision." Cells derived from embryos lacking p190-B...

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Source

Identifiers

PMID: 12705864
DOI: 10.1016/s0092-8674(03)00271-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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