Article
Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development.
Developmental cell - 1 May 2002
Sordella Raffaella, Classon Marie, Hu Kang Quan, Matheson Stephen F, Brouns Madeleine R, Fine Barry, Zhang Le, Takami Hiroya, Yamada Yoshihiko, Settleman Jeffrey
Abstract excerpt
Rho GTPases regulate several aspects of tissue morphogenesis during animal development. We found that mice lacking the Rho-inhibitory protein, p190-B RhoGAP, are 30% reduced in size and exhibit developmental defects strikingly similar to those seen in mice lacking the CREB transcription factor. In p190-B RhoGAP-deficient mice, CREB phosphorylation is substantially reduced in embryonic tissues. Embryo-derived...
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