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Transcriptional changes revealed genes and pathways involved in the deficient testis caused by the inhibition of alkaline ceramidase (Dacer) in Drosophila melanogaster.

Archives of insect biochemistry and physiology - 1 Mar 2021

Zhang Min-Jing, Shi Xiao-Xiao, Wang Ni, Zhang Chao, Zhang Chunhong, Quais Md Khairul, Ali Soomro Abid, Zhou Wenwu, Mao Cungui, Zhu Zeng-Rong

Abstract excerpt

Sphingolipids are ubiquitous structural components of eukaryotic cell membranes which are vital for maintaining the integrity of cells. Alkaline ceramidase is a key enzyme in sphingolipid biosynthesis pathway; however, little is known about the role of the enzyme in the male reproductive system of Drosophila melanogaster. To investigate the impact of alkaline ceramidase (Dacer) on male Drosophila, we got Dacer...

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PMID: 33590535
DOI: 10.1002/arch.21765

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