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Article

Disruption of sphingolipid metabolism elicits apoptosis-associated reproductive defects in Drosophila.

Developmental biology - 15 Sept 2007

Phan Van H, Herr Deron R, Panton Dionne, Fyrst Henrik, Saba Julie D, Harris Greg L

Abstract excerpt

Sphingolipid signaling is thought to regulate apoptosis via mechanisms that are dependent on the concentration of ceramide relative to that of sphingosine-1-phosphate (S1P). This study reports defects in reproductive structures and function that are associated with enhanced apoptosis in Drosophila Sply05091 mutants that lack functional S1P lyase and thereby accumulate sphingolipid long chain base metabolites....

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Identifiers

PMID: 17706961
DOI: 10.1016/j.ydbio.2007.07.021
PMCID: PMC2094363

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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