Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular and functional analysis of Shiga toxin–induced response patterns in human vascular endothelial cells

22 Apr 2003

Abstract excerpt

Enterohemorrhagic Escherichia coli (EHEC) is the major cause of hemolyticuremic syndrome (HUS) characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. EHEC produces one or more Shiga toxins (Stx1 and Stx2), and it was assumed that Stx's only relevant biologic activity was cell destruction through inhibition of protein synthesis. However, recent data indicate that in vivo the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement system in diseases
Share to Escherichia coli research studies
Share to Viral gastroenteritis research and epidemiology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12702508
DOI: 10.1182/blood-2002-10-3301

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular and functional analysis of Shiga toxin–induced response patterns in human vascular endothelial cellsPMID 12702508Read ↗

Synergy of LPS and Shiga-toxin exposure on the RNA expression program of cultured human umbilical vein endothelial cellsSemantic proximity Read ↗

New Aspects in the Pathogenesis of Enteropathic Hemolytic Uremic SyndromeSemantic proximity Read ↗

Shiga Toxins: An Update on Host Factors and Biomedical ApplicationsSemantic proximity Read ↗

Molecular Biology of Escherichia coli Shiga Toxins’ Effects on Mammalian CellsSemantic proximity Read ↗

Genetic Susceptibility to Postdiarrheal Hemolytic-Uremic Syndrome After Shiga Toxin-Producing Escherichia coli Infection: A Centers for Disease Control and Prevention FoodNet Study.Semantic proximity Read ↗

Enteropathogenic and Enterohemorrhagic <i>Escherichia coli</i> Virulence Gene RegulationSemantic proximity Read ↗

Specific Interaction of Escherichia coli 0157:H7-Derived Shiga-like Toxin II with Human Renal Endothelial CellsSemantic proximity Read ↗

Shiga toxin remodels the intestinal epithelial transcriptional response to Enterohemorrhagic Escherichia coliSemantic proximity Read ↗

Shiga toxin-associated hemolytic uremic syndrome: advances in pathogenesis and therapeutics.Semantic proximity Read ↗

Heme as Possible Contributing Factor in the Evolvement of Shiga-Toxin Escherichia coli Induced Hemolytic-Uremic Syndrome.Semantic proximity Read ↗

Verotoxin biology: molecular events in vascular endothelial injury.Semantic proximity Read ↗

Functional Capacity of Shiga-Toxin Promoter Sequences in Eukaryotic CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.