Article

Synergy of LPS and Shiga-toxin exposure on the RNA expression program of cultured human umbilical vein endothelial cells

2024-11-03

Abstract excerpt

<h4>Background</h4> Hemolytic uremic syndrome (HUS) is a primary thrombotic microangiopathy that can cause acute renal failure, particularly in children, and is commonly triggered by Shiga toxin-producing Escherichia coli (STEC) infection. Although previous in vitro studies have shown that Shiga toxin (STX) can directly affect the endothelium, gram-negative bacteria such as E. coli also contain lipopolysacchar...

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Literature Corpus work: b5840fb2-2b72-59cc-b271-a40458462b74
DOI: 10.1101/2024.10.30.621129

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