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Functional Capacity of Shiga-Toxin Promoter Sequences in Eukaryotic Cells

22 Feb 2013

Abstract excerpt

Shiga toxins (Stx) are the main virulence factors in enterohemorrhagic Escherichia coli (EHEC) infections, causing diarrhea and hemolytic uremic syndrome (HUS). The genes encoding for Shiga toxin-2 (Stx2) are located in a bacteriophage. The toxin is formed by a single A subunit and five B subunits, each of which has its own promoter sequence. We have previously reported the expression of the B subunit within the...

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PMID: 23451160
DOI: 10.1371/journal.pone.0057128

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